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Johnson ECB, Kent SBH (2006) Studies on the insolubility of a transmembrane peptide from signal peptide peptidase. J Org Chem 59:1745–1750īurlina F, Papageorgiou G, Morris C, White PD, Offer J (2014) In situ thioester formation for protein ligation using α-methylcysteine.
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Quibell M, Turnell W, Johnson T (1994) Preparation and purification of beta-amyloid (1–43) via soluble, amide backbone protected intermediates. Paradís-Bas M, Tulla-Puche J, Albericio F (2014) 2-Methoxy-4 methylsulfinylbenzyl: a backbone amide safety-catch protecting group for the synthesis and purification of difficult peptide sequences. Org Biomol Chem 13:1500–1506Ĭardoso RM, Zwick MB, Stanfield RL, Kunert R, Binley JM, Katinger H, Burton DR, Wilson IA (2005) Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Huang YC, Guan CJ, Tan XL, Chen CC, Guo QX, Li YM (2015) Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones. J Org Chem 65:5460–5468Įde NJ, Ang KH, James IW, Bray AM (1996) Incorporation of 2-hydroxy-4-methoxybenzyl protection during peptide synthesis via reductive alkylation on the solid phase. Miranda LP, Meutermans WD, Smythe ML, Alewood PF (2000) An activated O→ N acyl transfer auxiliary: efficient amide-backbone substitution of hindered “difficult” peptides. Chem Commun 50:8316–8319Ībdel-Aal AM, Papageorgiou G, Raz R, Quibell M, Burlina F, Offer J (2016) A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation. Tetrahedron Lett 38:9047–9050Ībdel-Aal AM, Papageorgiou G, Quibell M, Offer J (2014) Automated synthesis of backbone protected peptides. Offer J, Johnson T, Quibell M (1997) Application of reversible amide-bond protection to suppress peptide segment epimerization. Angew Chem Int Ed 49:10149–10153Ĭardona V, Eberle I, Barthelemy S, Beythien J, Doerner B, Schneeberger P, Keyte J, White PD (2008) Application of DMB-dipeptides in the Fmoc SPPS of difficult and aspartimide-prone sequences. J Pept Sci 10:18–26Įl Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H (2010) Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. White P, Keyte JW, Bailey K, Bloomberg G (2004) Expediting the Fmoc solid phase synthesis of long peptides through the application of dimethyloxazolidine dipeptides. Goncalves V, Gautier B, Huguenot F, Leproux P, Garbay C, Vidal M, Inguimbert N (2009) Total chemical synthesis of the D2 domain of human VEGF receptor 1. Wöhr T, Mutter M (1995) Pseudo-prolines in peptide synthesis: direct insertion of serine and threonine derived oxazolidines in dipeptides.
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Use in the synthesis of difficult sequences. Johnson T, Quibell M, Owen D, Sheppard RC (1993) A reversible protecting group for the amide bond in peptides.
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Org Lett 17:3521–3523īeyermann M, Bienert M (1992) Synthesis of difficult peptide sequences: a comparison of Fmoc-and Boc-technique. Dang B, Dhayalan B, Kent SB (2015) Enhanced solvation of peptides attached to “Solid-Phase” resins: straightforward syntheses of the elastin sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val.
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